Some Complicated Angles of Weight

Although styles of therapy differ, it is widely accepted that the root of all psychological malfunction is pain. In the animal kingdom, the amoeba is about as simple a creature as can be. And yet, even the humble amoeba knows to avoid pain, and somehow recognizes the appropriate moment to flee from a molecule of poison.

In that respect, people are very much like amoebae, but have more freedom of choice in their reactions. Amoebae probably can’t even fight. Their choice of displacement activity is quite limited.

Now, what about the entities that facilitate the healing of pain? Psychologists, for instance — do they absolutely need to be human?

As we have discussed, one aspect of psychological therapy has developed quite rapidly and noticeably into an overwhelming issue. Can excellent results be achieved with less, or even zero, human interaction? Can human connection be adapted and reconceptualized into something equally curative, by perfecting the ability of Artificial Intellligence to imitate high-quality connection?

It’s not that surprising

One might ask, why shouldn’t this be the case? Look, for instance, at books. They are made from common materials, and from symbols that are very different from human speech or breath. Furthermore, vast numbers of humans have been and still are unable to read books — and yet the influence that books have exerted on many of us (for better or worse) throughout the ages is a true marvel.

An important aspect of convincing relatability is in the bag already. Thanks to technology, AI can be engineered to swindle people out of their life savings by speaking in a voice so relatable that a perfectly sane adult will think it’s their grandkid, in desperate need of bail money. Compared to such an accomplishment, the ability to sound like the world’s most empathic therapist is no big deal.

One thought leads inevitably to another

So, why shouldn’t an equally convincing fake entity succeed in helping a person feel worthy and capable of making enormous life changes and losing 100 pounds? Or, if the human in need of therapy is a child wouldn’t it be theoretically possible to dispose of breath and heartbeat entirely, and let AI help the kids adopt, painlessly, a lifestyle through which they would never become overweight in the first place?

How much actual personal contact between patient and therapist is actually optimal? Can a group of other people with similar problems serve the personal-connection need just as well?

Maybe so. Millions of group therapy participants will attest that to go through the self-discovery experience with a cohort of similarly affected others can be incredibly helpful. For many, it has been vital to associate with others who are on the same basic journey, but a little bit ahead.

As Alcoholics Anonymous and similar groups have demonstrated, we also benefit from hanging out with people who travel a little way behind us so we can take our well-deserved turn as experienced encouragers of others on the same path.

(To be continued…)

Image by dbutlerdidit/Pixabay

New Gut Research for Obesity and Diabetes

Scientists have long suspected that the trillions of microbes living in our gut do more than help digest food. Now, new research suggests they may play a direct role in shaping how our bodies handle sugar and fat — key factors in obesity and type 2 diabetes.

A recent study conducted at Harvard University, with support from Brazil’s São Paulo Research Foundation (FAPESP), has uncovered a network of small molecules produced by gut microbes that travel from the intestine to the liver and then throughout the body. These compounds, known as metabolites, appear to influence how the liver processes energy and how sensitive the body is to insulin. The findings were published in the journal Cell Metabolism and could open the door to new ways of treating metabolic disease.

The gut–liver highway

To understand the discovery, it helps to know how blood flows through the body. Much of the blood leaving the intestine doesn’t go straight into the general circulation. Instead, it travels through a special vessel called the hepatic portal vein, which delivers nutrients and microbial byproducts directly to the liver first.

“The liver is essentially the first organ to see what’s coming from the gut,” explains lead author Vitor Rosetto Muñoz, a postdoctoral researcher at the University of São Paulo who conducted part of the study at Harvard’s Joslin Diabetes Center. Once these gut-derived compounds reach the liver, they can be modified, broken down, or released into the bloodstream to affect other organs.

By comparing blood from the hepatic portal vein with blood circulating throughout the rest of the body, the researchers were able to pinpoint which metabolites come from the gut and how they may influence metabolism along the way.

Why the gut microbiome matters

In recent years, researchers have learned that people with obesity, insulin resistance, or type 2 diabetes often have a different mix of gut bacteria than people without these conditions. What’s been harder to determine is exactly how those microbes affect metabolism.

To explore this, the team studied mice with different genetic risks for obesity and diabetes. They analyzed metabolites in both portal vein blood and peripheral blood, offering a clearer picture of what the liver is exposed to right after digestion.

In healthy mice, researchers identified more than 100 metabolites enriched in blood traveling from the gut to the liver. But in mice genetically prone to obesity and diabetes (and fed a high-fat diet), that number dropped dramatically. This suggests that diet and genetics together can reshape the chemical messages sent from the gut to the liver.

Interestingly, mice that were naturally resistant to metabolic disease showed a different metabolite pattern altogether. This points to a complex interaction between a person’s genes, their environment, and their gut microbiome.

Disrupting the microbiome changes metabolism

To test whether gut bacteria were truly responsible for these changes, researchers treated some mice with antibiotics that altered their gut microbiome. As expected, this disrupted microbial populations and also shifted the types of metabolites found in the blood.

One metabolite that increased stood out: mesaconate, a compound involved in the Krebs cycle, which is the process cells use to generate energy. When scientists exposed liver cells to mesaconate and related molecules in the lab, they saw improvements in insulin signaling. The compounds also helped regulate genes linked to fat buildup and fat burning in the liver — two processes that are often impaired in metabolic disease.

These findings suggest that certain gut-derived metabolites can directly improve liver metabolism, even in the context of a high-fat diet.

What this could mean for the future

While this research was done in mice, it provides a detailed map of how gut microbes may influence metabolic health through the liver. The next step is to better understand how each metabolite is produced and how it behaves in the body.

Over time, this work could help scientists identify specific microbial byproducts that might be used as treatments—or inspire therapies that reshape the gut microbiome to improve insulin sensitivity and reduce the risk of obesity and type 2 diabetes.

So, remember: What happens in your gut doesn’t stay in your gut. It may travel straight to your liver and shape your metabolic health in powerful ways!

Your responses and feedback are welcome!

Source: “Harvard gut discovery could change how we treat obesity and diabetes,” ScienceDaily, 12/14/25
Source: “Metabolites produced in the intestine play a central role in controlling obesity and diabetes,” Agencia.fapesp.br, 11/26/25
Source: “Portal vein-enriched metabolites as intermediate regulators of the gut microbiome in insulin resistance,” ScienceDirect, 10/7/25
Image by Wassily Kandark/Pexels

So, relax. Eat cake.

Not long ago, we mentioned the experience of Kris, who totally recognized how much her emotional health depended on feeling so massively immovable that she could not be knocked down and rendered helplessly vulnerable. (To state it more theatrically, and sadly, she could absolutely never be “swept off her feet,” either, which was all according to plan).

As we have seen, Richard C. Schwartz and (unrelated) Mark Schwartz spent a decade refining the philosophies and practices of Internal Family Systems, stressing “the importance of working with the eating disordered part of self that encapsulates the trauma of the past.” The materials written for the public explained that, in contrast to other existing treatment facilities, Castlewood helped clients to heal the pain beneath their eating disorders “rather than just manage the symptoms.” They got in touch with their “parts” — the various inner beings known as Exiles, Managers, Firefighters, and other types.

When worlds collide

It seems unfair that even people who grow enough to accept and follow advice will still mess up so badly in choosing which advice to adopt. When taking action, it is also important to do the least possible harm. Listening to the wrong person and/or the lousy advice can be a problem at home, in group therapy, and basically whenever someone sets out to claim agency.

We could say that Kris had an inner advisor who advocated staying massively overweight for the sake of safety. And to all intents and purposes, it worked. But here is the problem. A “part,” be it manager, exile, firefighter, or whatever, could be mistaken in its opinion, and might be a wrong-headed advisor, just like a regular human. Real people and “parts” can all be mistaken, and so might people with degrees and headlines. And so might AI.

Important note: When a counselor helps a patient to identify the decent protective impulses that drive the parts called “firefighter” or “manager,” this is for identification purposes only, and does not imply endorsement or recommendation. To provide meaningful service, the professional really needs to have a handle on what’s what.

Today’s illustration features a slogan that has been seen, with creative variations, many times over the years, but to track and credit the original author would probably be impossible. Our most recent post asked if it is possible to facilitate the healing process without the participation of any actual second human.

And why not?

Well, why shouldn’t this be the case? It has already happened. Look, for instance, at books. They are made from common materials and from symbols that are very different from human speech or breath. Furthermore, vast numbers of humans have been and still are unable to read books — and yet the influence that books have exerted on humanity (for better or worse) is a true marvel.

Now, the real world connection, in-the-flesh, in the same space-time — how much of that is the minimum amount needed; the “necessary but not sufficient condition” that would be required to cause an effect? Is it the same in every case, and if not, then how do we tell the difference and decide how to proceed?

Okay, how about not very much?

One aspect of that psychological challenge has developed quite rapidly and noticeably into an overwhelming issue. Can excellent results be achieved with minimal human interaction, or even none at all? If the ability of AI to imitate high-quality connections could be perfected, then what? Well, first of all, forget all that, because it doesn’t meet the criterion of being human.

But what if AI works anyway? What if it learns to function incredibly well? Then, could human connectivity catch up and be similarly effective? Could human connection be adapted and re-conceptualized into something equally therapeutic?

Some people will always insist that AI is not human: end of story. Likely, there will always be others who insist that, of course, AI is drenched in humanity because people conceived and created it, and trained it on the works of thousands of unpaid creators, and so forth. Most likely, it is too soon to know.

Your responses and feedback are welcome!

Source: “The Therapy That Can Break You,” TheCut.com, 10/30/25
Image by Iffany/Pixabay

How Much Connection?

How often does it happen that a perfectly valid therapeutic approach fails, although there may be nothing wrong with that approach whatsoever? Maybe, for example, an outside force exerts a negative influence on the relationship between a therapist and the person being counseled. Among adults, an insecure partner, especially one who lives with the patient, can sabotage weight-loss efforts with ease.

In a far different setting, on the conceptual level, there may be difficulties, like those that can occur in the implementation of Internal Family Systems (IFS) theory. This modality is said to be designed for patients 18 and older, and may seem to have only a slight connection with childhood obesity — at the moment.

But if our current offspring emerge from their teens still carrying extra weight, the popularity of IFS guarantees that they will run into it sooner or later. It claims to be very successful in dealing with weight-control issues centering around either substance addiction (to food itself), or behavioral addiction (to the process of eating). IFS raises questions that may seem to stray far afield, but which provide glimpses into areas of human psychology that are quite different from jogging for miles, juggling calories, or judging portion sizes.

Human frailty never ends

In the Sixties, group therapy became popular and helped scads of people with various problems. There was a lot less obesity in those days, but for some folks, it was their main difficulty. For them, and many other types of help-seekers, there were side effects.

What if, during every group therapy session, a patient was fantasizing… “I’ll lose so much weight, and at our anniversary parties, I’ll tell the story of how we met because I couldn’t fit into my jeans, but my doctor fell in love with me. And he/she will playfully pinch my bottom, and all our friends will laugh and laugh…”

This is a tempting road to explore, because in the hearts and minds of most psychological counseling participants, to win the approbation of the therapist is golden. It is a powerful drive, and the possibility exists for a patient of any age or sexual orientation to develop very strong, situationally inappropriate feelings toward their therapist.

Another question

How heavy an effect does this need for approval, validation, and love exert in already-established obesity prevention programs? Everyone who enters therapy might not visualize an engagement ring, but plenty of us like to believe that we are the favorite patient, the one whose astonishing improvement makes it all worthwhile, not like those ordinary schlubs our therapist merely tolerates.

How does it tend to work out, for instance, in IFS, where the therapist has a chance to become acquainted with not just one aspect of the help-seeker, but with an entire cast of interior characters, each one of them whispering into the patient’s ear whenever they feel like it?

The future is now

All of this brings up a much bigger and potentially more dreadful problem that gains ground daily. Never mind being the favorite patient. Do we really, really need our psychological maladies to be addressed by a human intelligence or consciousness, at all? Or, for therapy to succeed, can a mere simulacrum do the trick? If we truly require a certain amount of human attachment in this context, how can the most useful amount of it, along with the correct amount of intellectual and emotional content, be achieved and maintained?

A human connection, whether through office visits or online counseling sessions, can affect a patient at any age, though with varying manifestations. In the case of weight-related problems, the relationship involves ideas and emotions about the body, and this additional dimension can be tricky.

What happens when human practitioners are replaced by chat robots and artificial intelligence? How has that method succeeded so far? In light of recent news reports about teenagers persuaded to commit suicide by human-imitating AI programs, the very existence of such an abomination is terrifying. (On the other hand, the issue becomes more complicated when, for instance, we learn that AI counseling may be of great help in preventing suicide among military veterans.)

Two views

Getting back to Internal Family Systems, here are two pertinent quotations from an article by Rachel Corbett, who conveys some of Richard Schwartz’s ideas about how the method that he originated (and developed at Castlewood Treatment Center) “is really the opposite of fragmenting people.” Corbett writes,

Clients come into treatment with their parts already intact — like a bulb of garlic, rather than the layers of an onion, he has said — “It’s not like I’m creating them.” Instead, IFS therapists work on “rounding up all those outlying parts and bringing them back home.”

Corbett views it all from another angle (and more about that is coming up next time). She cautions:

Most of Castlewood’s methods, starting with its use of IFS and the focus on trauma, contradict the prevailing playbook for treating eating disorders. Dredging up harrowing memories can overwhelm already fragile psyches and may lead to self-harm, substance abuse, or other unhealthy coping behaviors.

Your responses and feedback are welcome!

Source: “The Therapy That Can Break You,” The Cut, 10/30/25
Image by ThomasWolter/Pixabay

GLP-1 Medications Should Be Paired With Lifestyle Modifications

GLP-1–based therapies, popularized by medications like semaglutide and tirzepatide, are reshaping the way we think about obesity, metabolic health, and even chronic disease prevention. While these drugs first gained widespread attention for supporting significant weight loss, new research shows their influence reaches deep into multiple body systems.

At UC Davis Health, experts are taking a comprehensive look at how GLP-1 medications affect the entire body, from the gut and brain to the heart, muscles, and bones. Their findings point to a future where obesity treatment is not only more effective but also more holistic.

According to Miranda Stiewig-Rapp, assistant professor of endocrinology at UC Davis Health and incoming director of the system’s new Obesity Clinic (opening in 2026), GLP-1 agonists are redefining what’s possible in medical weight management.

Early clinical trials show average weight loss of 15-20%, compared to the 5-10% typically achieved with earlier generations of medication. And while these drugs offer powerful support, experts emphasize that pairing them with lifestyle changes creates the strongest outcomes.

The systemic impact of GLP-1 therapies

UC Davis Health recently brought together leading scientists, clinicians, researchers, and industry innovators to examine how GLP-1 drugs influence the body as a whole. Their findings reveal broad metabolic shifts that reinforce the importance of personalized nutrition, fitness, and long-term support.

The gut

GLP-1 slows gastric emptying, a mechanism that helps regulate blood sugar and prolong satiety. But it also influences the trillions of microbes that make up the gut microbiome.

These medications change how food moves through the digestive tract and alter fermentation patterns — shifts that can reshape the microbiome itself. A healthier microbiome can improve insulin sensitivity and support the metabolic benefits of GLP-1 therapies.

However, gastrointestinal side effects such as nausea, vomiting, or diarrhea remain common as the body adjusts. Supporting gut health with probiotics, fiber, and nutrient-dense meals can help minimize discomfort.

The brain

GLP-1 signals travel to the brain through the bloodstream and vagus nerve, reducing hunger and quieting the persistent “food noise” many patients describe.

Emerging research suggests that GLP-1 therapies may also influence reward pathways, potentially affecting cravings for sweets, fatty foods, and even substances like nicotine or alcohol. With appetite and reward signaling both shifting, many patients find it easier to adopt healthier eating patterns.

The muscles

While GLP-1 medications promote fat loss, rapid weight reduction may also lead to a loss of lean mass. Experts note that 15-25% of weight lost during calorie reduction — whether through medication or diet — can be lean mass.

Maintaining physical activity and prioritizing high-quality protein are essential for preserving muscle and keeping metabolism strong. Resistance training and structured exercise plans remain important companions to GLP-1 therapy.

The bones

Bone is metabolically active and responds to hormonal shifts, including those influenced by GLP-1. Rapid weight loss, reduced food intake, and nutrient gaps can place extra stress on bone density, especially in older adults and postmenopausal women. A balanced diet rich in calcium, vitamin D, magnesium, and protein, along with weight-bearing exercise, helps protect bone strength during GLP-1 therapy.

The heart

Beyond blood sugar control and weight loss, GLP-1 receptor agonists offer significant cardiovascular protection. Clinical trials show they reduce the risk of major heart events such as heart attack and stroke. Multi-agonist medications that combine GLP-1 with GIP or glucagon may enhance these heart benefits even further by improving fat metabolism and reducing inflammation.

Nutrition matters more than ever

Because GLP-1 medications suppress appetite, patients often eat less, which can make it harder to get the nutrients the body needs. Precision nutrition approaches can help close these gaps. The recommendations include choosing smaller, nutrient-dense meals; prioritizing high-quality protein; taking vitamins like B12, D, folate, magnesium, and iron; staying hydrated; and supporting gut health with probiotics and fiber.

Behavioral insights and BrainWeighve

At the 2025 conference on Obesity and Chronic Diseases (ICOCD) in Boston in November, Dr. Robert Pretlow, publisher of Childhood Obesity News, presented emerging insights into how GLP-1 medications interact with behavior, reward, and lifestyle habits. Dr. Pretlow’s core message was clear: GLP-1 medications work best when paired with lifestyle modification.

Dr. Pretlow is the creator of BrainWeighve, a weight loss app for overweight and obese children. In breaking news, Dr. Pretlow announced that the BrainWeighve clinical trial at U.C.L.A. has expanded to include 10 subjects currently taking GLP-1 medications. This addition aims to help researchers understand how lifestyle and behavioral tools can enhance — or possibly even reduce — the need for medication over time.

How GLP-1s affect the reward system

The mechanism of action for GLP-1 agonists is believed to involve the inhibition of reward cues, which may reduce cravings and compulsive eating behaviors. This could help “quiet” displacement mechanisms — behaviors people use to soothe emotional or psychological discomfort through food.

But a key question remains: What happens if displacement is never addressed?

According to Dr. Pretlow, pairing displacement interventions with GLP-1 therapy may allow patients to use lower doses of medication, support tapering off GLP-1s over time, help non-responders gain better results, and provide long-term tools for managing eating addiction and emotional hunger.

These early findings suggest that displacement activities — redirecting urges into harmless or productive behaviors — may offer meaningful support to individuals struggling with overeating.

The BrainWeighve study

These concepts are at the heart of BrainWeighve, a behavior modification and weight loss app currently in clinical trials at UCLA. The program is designed for obese teens and uses a self-directed, physician-supervised approach to tackle overeating one “problem food” at a time.

By helping participants rechannel emotional urges into healthier coping mechanisms, BrainWeighve aims to support sustainable weight loss — and reduce dependence on willpower alone.

As Dr. Pretlow summarized in his presentation:

Displacement activity may provide individuals with hope that they can curb overeating without relying entirely on medication or willpower.

Your responses and feedback are welcome!

Source: “UC Davis Health examines systemic impact of GLP-1–based therapies,” UC Davis Health, 12/5/2025
Source: “Treatment of Eating Addiction and Obesity As Displacement Activity: A Pilot Study,” ICOCD presentation, 11/7/25
Image by Dr. Pretlow

Listening to Internal Advice

It is worth mentioning here that many people, even in the healing professions, tend to discount emotional pain, as if it were a mere inconvenience or even a whim that someone can simply choose to shrug off. There seems to be a “Just say no to emotional pain” school of thought that tends not to work out well in everyday life. Really, the only people who “get” how crippling emotional pain can be are those whose lives are impoverished by it.

This might be why some practitioners obviously see great value in a basic Internal Family Systems concept, which is:

[D]isordered eating behaviors are not the problem themselves but rather attempts by protective parts to manage deeper emotional pain.

The internal beings called “parts” are also sometimes known as sub-personalities, thoughts, ideas, internal dialogue, feelings, sensations, symptoms, behaviors, defense mechanisms, maladaptive coping strategies, or even spirits.

The crowd

Among the inner multitude, one category of respondent, known as a “manager,” wants to protect the host and might be interested in setting up some rules. Also, those might be counterproductive rules that will wind up creating even more pain in the end. A manager sees a problem and proposes a solution, and strives to make something happen, even if it isn’t the optimal thing. Still, the managerial parts probably tend to have more common sense than those even more proactive parts that leap into the fray — known as “firefighters.”

Firefighters operate under a different set of criteria. They suit up, grab high-pressure hoses, mount ladders, and rush in to try and save the day. Their mission is to stop the immediate threat of psychic violence and destruction, even if it entails physical violence and destruction. Their priority is to end the inner pain, right now. The impulsive firefighters can be like enthusiastic amateurs who mean well, but do a sloppy job. If the only way forward is to tear down the museum-quality ancestral drapes to smother the fire with, a reactive guardian will do it.

Or that over-amped protector might pull some stunt like a spending spree, an unwise date, self-harm, violence, or even suicide. More likely, to terminate the current discomfort, this misguided volunteer might send the person on an eating binge. Sure, that is a variety of self-harm, but it smothers the present, in-your-face pain.

Thanks a lot

A binge is harmful enough, but there are, in fact, other shades and nuances of damage that must be written off as the inevitable consequence of avoiding immediate pain. Conversely, but for the same purpose of escaping today’s pain, tomorrow’s opportunity to heal might be put at risk by purging. If things continue badly, the firefighter’s next suggestion might be to exercise compulsively, or to try some nice numbing opiate.

Of course, all of this activity, however misguided or futile, takes place to protect the Exiles, the “parts” who are like ossified copies of the person at crucial stages when shattering life events took place. They broke off and live like hungry ghosts, unable to reconcile the horrible experiences they went through with a desire to keep on living, and yet unable to give up life as long as the tough old meat body is still hanging in there.

So, why not punish that animated corpse in some way, like the way that is so easily available in almost every society on Earth these days — by piling on the bulk until life becomes undesirable, and is sustainable only at a very high cost in daily pain?

Your responses and feedback are welcome!

Source: “Internal Family Systems and Eating Disorders: A Compassionate Approach to Recovery,” BalancedAwakening.com, undated
Source: “The IFS Model With Eating Disorders: ED is Just a Part of You,” EatingDisorderHope.com, undated
Image by cottonbro studio/Pexels

Parts and More Parts and IFS

Many professionals have explained and elaborated on the theories, called Internal Family Systems (IFS), of Dr. Richard Schwartz. It’s all about the “parts” — or inner beings — that inhabit psychologically troubled people. In what is perhaps a vain attempt to understand why these childhood-obesity-related teachings have caught on in such a big way, we consult yet another explainer, this time, writer Tess Brieva.

Overall, there seems to be a consensus that the various parts all aim to do the same job in different ways. That main task is to help the patient figure out, “Why am I doing this to myself?” Or perhaps, “Why are we doing this to ourselves?” Bottom line is, they all, in their unique ways, struggle to ultimately blend together into a single, healthy being.

One problem is, some of the parts are misguided, and every effort they make to avoid causing pain to the “exile” parts will only cause new problems. A “firefighter,” for instance, being an emergency first responder, might recommend an obvious cure that will distract and comfort the human host quickly, but alas, only temporarily. Brieva writes,

A binge-eating part might believe it’s helping by offering temporary comfort from emotional pain, while a restrictive eating part may believe it’s creating safety through control.

Then — just like small children when Mommy and Daddy fight — the “exile” parts experience even more fear, loneliness, shame, separation, and other negative emotions. Their problems are compounded, and another cycle of attempted compensation begins.

“It’s above my pay grade”

This author characterizes the “manager” parts as proactive, and anxious to avoid such obstacles as, for instance, painful emotions. Sadly, those efforts to dodge suffering only generate more problems, like, for instance, unreasonable rules and unachievable standards. It all gets to be just one big dysfunctional merry-go-round, with every part clueless about how to make the darn thing grind to a halt so everybody can get a grip.

Apparently, the basic goal of Internal Family Systems is to rope all those confused yet earnestly striving inner beings onto the “same page.” Or at least, singing from the same hymnal. Brieva explains what stands in the way of that peaceful resolution:

In eating disorders, managers and firefighters are usually polarized, creating inner conflict and a sense of confusion, turmoil, or stagnation. Protector parts in these extreme roles often lead to yo-yo dieting, restrict-binge cycles, and other unstable patterns.

Nobody wants to live with a bunch of different voices yammering away inside their head, and IFS makes a valiant effort to carve a new path to a better way. As the author explains,

IFS encourages individuals to explore the underlying intentions of their parts and uncover the deeper wounds driving those behaviors. Healing becomes possible when all parts are welcomed, listened to, and guided by the Self toward new ways of being.

Then, she clarifies that listening to and understanding the different internal parts, and their various plans for correcting the situation, does not imply approval. The therapist “does not necessarily condone or support this behavior,” because obviously some of the protective plans made by firefighters and managers are anti-social, self-harming, or otherwise counterproductive.

While the intentions are good, the methods may just cause more trouble, and this is what all the inner parts, it is hoped, will understand, and then figure out more effective methods for their healing process. It’s like a club where some members misbehave, but nobody gets kicked out, because the goal is to convert them into team members, who will then help to bring those other slackers into line.

Your responses and feedback are welcome!

Source: “Internal Family Systems and Eating Disorders: A Compassionate Approach to Recovery,” BalancedAwakening.com, undated
Image by kirill_makes_pics/Pixabay

WHO Releases First Global Guidelines on Weight-Loss Medicines

The World Health Organization (WHO) has issued its first-ever guideline on a new generation of weight-loss medications — a major move that could reshape global obesity treatment as rates continue to climb.

The recommendations center on GLP-1 therapies, a fast-growing class of drugs that includes liraglutide, semaglutide, and tirzepatide. WHO’s new guidance offers conditional recommendations on how these medicines can be used safely and effectively as part of long-term obesity care.

A growing global crisis

Obesity now affects more than one billion people worldwide, contributing to an estimated 3.7 million deaths in 2024. Without stronger action, the WHO warns the number of people living with obesity could double by 2030. This surge poses enormous challenges for healthcare systems and could result in $3 trillion in annual economic losses.

Given WHO’s role as the world’s leading public health authority, the new guideline is expected to influence national policies, insurance decisions, and clinical practices at a time when demand for effective weight-loss treatments is exploding.

WHO Director-General Tedros Adhanom Ghebreyesus commented:

Obesity is a major global health challenge. Our new guidance recognises that obesity is a chronic disease that can be treated with comprehensive and lifelong care. While medication alone won’t solve this global health crisis, GLP-1 therapies can help millions overcome obesity and reduce its associated harms.

Obesity recognized as a complex and chronic condition

The WHO stresses that obesity is not simply due to poor lifestyle choices. Instead, it is a complex chronic disease shaped by genetics, biological factors, environment, and social conditions.

A recent mindbodygreen article stresses that:

What makes this announcement meaningful isn’t only the endorsement of medication; it’s the explicit recognition embedded within it.

The WHO is formally acknowledging obesity as a chronic, relapsing disease requiring comprehensive, lifelong medical management. Not a character flaw. Not a willpower deficit. A complex metabolic condition deserving the same comprehensive, lifelong care we afford any other chronic illness.

Obesity increases the risk of heart disease, type 2 diabetes, and several cancers, and it can also worsen outcomes for infectious diseases. For many individuals, long-term weight loss is extremely difficult without medical assistance.

GLP-1 therapies help by mimicking a natural hormone that regulates appetite, blood sugar, and digestion. These medications can trigger meaningful weight loss and significant health improvements.

WHO added GLP-1 therapies to its Essential Medicines List in 2025 for high-risk diabetes patients, and the new guideline now recommends long-term use for adults with obesity, except during pregnancy.

However, the guidance remains conditional because of limited long-term safety data, questions around maintaining weight loss after stopping treatment, high cost, and concerns about unequal access across regions.

Medication isn’t enough

A major theme throughout the guideline is that GLP-1 drugs cannot serve as a standalone solution. mindbody green chimes in:

The WHO’s new guidelines recommend these medications for long-term obesity management in adults (excluding pregnant women), but with a critical caveat: they must be combined with what the document calls “intensive behavioural interventions,” structured, ongoing programs involving nutrition counseling, physical activity support, and behavioral health services…

This integrated approach (pharmaceutical intervention plus foundational lifestyle medicine) represents the future of metabolic health. GLP-1 therapies can be powerful catalysts for change, but they work best when layered into a broader foundation of movement, nutrition, sleep, stress management, and community support.

WHO also highlights the broader need for systems-level action. Creating healthier food environments and early intervention programs requires cooperation between governments, healthcare providers, and industry, not just individual effort.

Ensuring access, affordability, and safety

Demand for GLP-1 medicines already far outpaces supply. Even with expanded manufacturing, the WHO estimates fewer than 10% of eligible people will have access by 2030. Without careful planning, this scarcity risks widening existing health inequities. To counter this, the WHO urges governments to consider pooled procurement, fair pricing strategies, and voluntary licensing agreements.

Another emerging issue is the rise of fake or substandard GLP-1 products, driven by global shortages. WHO stresses the importance of regulated supply chains, proper prescribing, and strong oversight to ensure patient safety.

WHO plans to update the recommendations as new research becomes available, and in 2026, the organization will work with global partners to prioritize access for people most at risk.

Your responses and feedback are welcome!

Source: “GLP-1 Medications Just Got WHO’s Backing — Here’s The Part You Can’t Ignore,” mindbodygreen.com, 12/1/25
Source: “WHO backs wider use of weight-loss medicines, calling obesity a chronic disease,” UN.org, 12/1/25
Source: “WHO issues global guideline on the use of GLP-1 medicines in treating obesity,” WHO.int, 12/1/25
Image by Karola G/Pexels

The Problematic Core of Internal Family Systems

Obviously, aspects of Internal Family Systems (IFS) might prove elusive or difficult to grasp. Why are patients with eating disorders said to be exceptionally difficult to treat? Why do so many sources mention the particular suitability of IFS to treat eating disorders? And yet, why do some experts consider it an unsafe form of psychotherapy?

If the popular Internal Family Systems philosophy is quite possibly dangerous, or even simply misguided, inconsequential, or otherwise unworthy of attention, why devote so many words to it? Because it cannot be ignored. The number of adherents and practitioners is startling. This may be because, despite sounding perhaps unlikely, some of the basic notions are either familiar enough to be comfortable with, or unfamiliar enough to be intriguing.

Although the tenets are controversial, they are by no means original. For example, we noted how, several decades ago, the popularity of a particular book was able to dramatically increase public awareness of multiple personality disorder. Once the existence of a new malady is confirmed, the day inevitably comes when the public will “take that ball and run with it,” as the saying goes.

Age of Aquarius

Along came the Sixties, when huge numbers of young (and not-young) Americans tuned in to ancient ideas, and turned on to new ones. Our society has entertained some interesting notions and practices. Although Richard C. Schwartz did not suggest this, a case could even be made that the additional inner beings he posited might originate from previous existences.

Each “part” is like you, because they all are you, and yet each brings to the table its own concerns, talents, and traumas. Over thousands of years, millions of humans have accepted the concept of reincarnation. It would not be difficult to interpret those voices as echoes from one’s own successive physical presences on Earth.

We see how people might be persuaded that each human contains a whole crowd of entities, all with different and important roles. Even if we are unable to prove it with science, most of us have experienced the feeling of not being ourselves, as if another driver had metaphorically taken the wheel and steered us to a bad place. Still, it is a matter for concern that large numbers of professionals have climbed on board with the multiple personality premise, a theory that is, after all, not amenable to proof.

Not uncomfortable yet?

Strong objections have been voiced regarding a corollary of IFS dogma that many experts do not accept, or at least have limited enthusiasm for. This is the idea that most early-life trauma has to do with sex. For decades, that carnal connection was mostly associated with Freud. It is not difficult to see why, even within the professional realm, it might draw negative attention.

As journalist Rachel Corbett discovered, some therapists, reviewers, and patients have embraced (maybe too enthusiastically) the apparently extensive connection between eating/food issues and early sexual trauma. Patients tend to want to please their therapists, and when multiple interior beings are proposed, are perhaps too eager to find those “parts” within themselves.

Especially when the patients or clients are minors, emphasizing this view of things can attract unfavorable attention. Regardless of how severe the problem is, or even how logically obvious it might appear that some type of sexually-oriented trauma could be the root of it, no practicing therapist wants a lawsuit involving an underage individual.

Your responses and feedback are welcome!

Source: “Internal Family Systems and Eating Disorders: A Compassionate Approach to Recovery,” BalancedAwakening.com, 12/01/25
Image by SHVETS production/Pexels

New Global Review Reveals Key Early-Life Factors Driving Childhood Obesity

A growing body of research has long suggested that the first years of life shape long-term health outcomes. Now, a major new analysis has brought unprecedented clarity to the early-life factors most strongly linked to childhood obesity — and what parents, healthcare providers, and policymakers can do to intervene earlier and more effectively.

According to the review,

A comprehensive new review of 177 global studies has pinpointed the strongest maternal and infant factors linked to childhood obesity in the first 1,000 days of life, offering insights to guide early prevention strategies.

A landmark global analysis

The review, “A major new systematic review, published this month by Obesity Reviews [the link is ours], has identified the most consistent maternal, paternal and infant factors linked to childhood obesity in the first 1,000 days of life.” Conducted by an international team from the Early Nutrition and Long-Term Health Task Force at ILSI Europe, the project represents the most extensive effort to date to map early-life influences on obesity risk.

As the report summarizes,

The researchers screened more than 17,000 publications and analysed 177 studies — including data from over 1.8 million children across 37 predominantly high-income countries. The average childhood obesity prevalence reported across these studies was 11 percent.

Ultimately, “In total, the team identified 23 risk factors consistently associated with a higher likelihood of childhood obesity.”

The strongest early-life risk factors

The findings underscore how maternal health, fetal development, and infant growth patterns collectively shape obesity risk. According to the review, the most influential factors include maternal health, and birth and infancy. In particular, “Higher maternal pre-pregnancy weight, excessive gestational weight gain and smoking during pregnancy.” And “Higher birthweight, being large for gestational age, lack of breastfeeding and rapid infant weight gain” for birth and infancy.

Critical knowledge gaps still remain

Despite the massive scope of the study, researchers warn that significant blind spots remain. As the report notes,

Despite the breadth of available evidence, the authors report several notable research gaps. These include limited study of paternal factors and the preconception period, as well as a lack of research using non-invasive biomarkers. The review also calls for more standardised data collection to support large-scale meta-analyses and more accurate models for predicting childhood obesity risk.

Closing these gaps, the authors say, will be essential for developing more accurate, personalized early-life obesity risk assessments.

Opportunities for earlier and more effective prevention

Research proves that multi-faceted intervention on an earlier side helps prevent childhood obesity. One of the central messages of the review is that intervention must begin before birth, and ideally even earlier. Chair of the expert group, Dr. Romy Gaillard, emphasized the importance of using the first 1,000 days as a window for prevention:

Parents-to-be or parents of newborns are in frequent contact with healthcare workers, and are often motivated to make lifestyle changes that benefit both their own health and the health of their children. Our systematic review provides the most comprehensive overview of family-based risk factors for childhood obesity from preconception to two years of age.

She also notes that improved predictive tools may transform how obesity prevention is delivered:

She added that improved early-life risk assessment, supported by advanced modelling, could help target prevention strategies more effectively.

This landmark review offers the clearest picture yet of how early-life environments shape obesity risk — and how early, targeted interventions may hold the key to reversing global childhood obesity trends. With evidence spanning millions of children and dozens of countries, the message is unmistakable: Supporting families before and after birth is not just beneficial — it is essential.

Your responses and feedback are welcome!

Source: “Risk Factors in the First 1000 Days of Life Associated With Childhood Obesity: A Systematic Review and Risk Factor Quality Assessment,” Obesity Reviews, 11/19/25
Source: “New systematic review reveals strongest early-life risk factors for childhood obesity,” New Food, 11/24/25
Source: “Multi-component school intervention reduces obesity and improves health behaviors in children: a cluster-randomized controlled trial,” Nature.com, 11/18/25
Image by Vanessa Loring/Pexels

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Profiles: Kids Struggling with Weight

Profiles: Kids Struggling with Obesity top bottom

The Book

OVERWEIGHT: What Kids Say explores the obesity problem from the often-overlooked perspective of children struggling with being overweight.

About Dr. Robert A. Pretlow

Dr. Robert A. Pretlow is a pediatrician and childhood obesity specialist. He has been researching and spreading awareness on the childhood obesity epidemic in the US for more than a decade.
You can contact Dr. Pretlow at:

Presentations

Dr. Pretlow’s invited presentation at the American Society of Animal Science 2020 Conference
What’s Causing Obesity in Companion Animals and What Can We Do About It

Dr. Pretlow’s invited presentation at the World Obesity Federation 2019 Conference:
Food/Eating Addiction and the Displacement Mechanism

Dr. Pretlow’s Multi-Center Clinical Trial Kick-off Speech 2018:
Obesity: Tackling the Root Cause

Dr. Pretlow’s 2017 Workshop on
Treatment of Obesity Using the Addiction Model

Dr. Pretlow’s invited presentation for
TEC and UNC 2016

Dr. Pretlow’s invited presentation at the 2015 Obesity Summit in London, UK.

Dr. Pretlow’s invited keynote at the 2014 European Childhood Obesity Group Congress in Salzburg, Austria.

Dr. Pretlow’s presentation at the 2013 European Congress on Obesity in Liverpool, UK.

Dr. Pretlow’s presentation at the 2011 International Conference on Childhood Obesity in Lisbon, Portugal.

Dr. Pretlow’s presentation at the 2010 Uniting Against Childhood Obesity Conference in Houston, TX.